MTOR Kinase Inhibitor PP242
Information
- Drug Name
- MTOR Kinase Inhibitor PP242
- Description
- Entry(CIViC)
- 5
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| breast cancer | PIK3CA MUTATION PIK3CA MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 21358673 | Detail |
| breast cancer |
PTEN DELETION ( ENST00000371953.8 ) PTEN DELETION ( ENST00000371953.8 ) |
D |
Predictive
|
Does Not Support
|
Sensitivity/Response | Somatic | 3 | 21358673 | Detail |
| breast cancer | PIK3R1 MUTATION PIK3R1 MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 2 | 21358673 | Detail |
| breast cancer |
ERBB2 AMPLIFICATION ( ENST00000269571.10 ) ERBB2 AMPLIFICATION ( ENST00000269571.10 ) |
D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 2 | 21358673 | Detail |
| colorectal cancer | EIF4EBP1 PHOSPHORYLATION EIF4EBP1 PHOSPHORYLATION | D |
Predictive
|
Supports
|
Resistance |
N/A
|
2 | 22262166 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| A panel of 31 breast cancer cell lines was tested ... | PIK3CA | PIK3CA MUTATION PIK3CA MUTATION | Sensitivity | true | CIViC Evidence | detail |
| In a panel of 31 breast cancer cell lines, 11 had ... | PTEN |
PTEN DELETION ( ENST00000371953.8 ) PTEN DELETION ( ENST00000371953.8 ) |
Sensitivity | false | CIViC Evidence | detail |
| Sensitivity to mTORC1/2 inhibitor PP242 was assess... | PIK3R1 | PIK3R1 MUTATION PIK3R1 MUTATION | Sensitivity | true | CIViC Evidence | detail |
| In a panel of 31 breast cancer cell lines with var... | ERBB2 |
ERBB2 AMPLIFICATION ( ENST00000269571.10 ) ERBB2 AMPLIFICATION ( ENST00000269571.10 ) |
Sensitivity | true | CIViC Evidence | detail |
| 12 CRC cell lines were evaluated. 40% of these wer... | EIF4EBP1 | EIF4EBP1 PHOSPHORYLATION EIF4EBP1 PHOSPHORYLATION | Resitance or Non-Reponse | true | CIViC Evidence | detail |